| 产品英文名称 | Anti-Cyclophilin B Monoclonal Antibody (7B2) |
| 产品中文名称 | 亲环蛋白B单克隆抗体（7B2） |
| 别名 | PPIB; CYPB; Peptidyl-prolyl cis-trans isomerase B; PPIase B; CYP-S1; Cyclophilin B; Rotamase B; S-cyclophilin; SCYLP |
| 克隆类型 | 单克隆 |
| 检测类型 | WB,IF,IHC-P |
| 反应性 | 人,大鼠,小鼠 |
| 宿主 | 小鼠 |
| 免疫原 | 合成多肽 |
| 样本类型 | WB#IHC-P#IF |
| 产品形式 | 液体形式 |
| 基因ID | 5479 |
| 目标条带分子量 | 21 |
| 蛋白序列链接 | http://www.uniprot.org/uniprot/P23284 |
| 存储缓冲液 | PBS缓冲液（pH 7.4），含有0.5%BSA（稳定剂），0.02％叠氮化钠（防腐剂）和50％甘油。 |
| 保存建议 | 自发货之日起，-20°C可稳定保存1年。为最大限度的避免损失，请在打开管盖之前融化抗体并离心。我们建议使用前分装以避免反复冻融。 |
| 运输条件 | 蓝冰运输 |
| 警告 | 本文列出的产品仅供研究使用，不适用于人类或临床诊断。我们产品所推荐应用，不是建议使用我们的产品去违反任何专利或许可证。对于使用本产品可能发生的专利侵权或其他违规行为，我们不承担任何责任。 |
| 背景 | Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents - cyclosporin A (CsA) or FK506. Proteins which bind FK506 are termed FK506 Binding Proteins (FKBP's) and those which bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation. Thus, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase's, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins. |
Fig. Western blot analysis of Cyclophilin B expression in Jurkat cells (lane A， 293T cells (lane B， Rat liver tissue (lane C) and 3T3 cells with Anti-Cyclophilin B Monoclonal Antibody (7B2) with 1:2000 dilutions.
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