| 产品英文名称 | Caspase-3 Polyclonal Antibody |
| 产品中文名称 | Caspase-3多克隆抗体 |
| 别名 | CASP3; CPP32; Caspase-3; CASP-3; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1 |
| 克隆类型 | 多克隆 |
| 检测类型 | IHC-P,WB,ELISA,IF |
| 反应性 | 小鼠,人,大鼠 |
| 宿主 | 兔 |
| 浓度 | 1 mg/ml |
| 免疫原 | 合成多肽：人源蛋白的中央区域， Caspase-3 |
| 样本类型 | WB#IF#IHC-P#ELISA |
| 产品形式 | 液体形式 |
| 基因ID | 836 |
| 蛋白序列链接 | http://www.uniprot.org/uniprot/P42574 |
| 存储缓冲液 | PBS缓冲液（pH 7.4），含有0.5%BSA（稳定剂），0.02％叠氮化钠（防腐剂）和50％甘油。 |
| 保存建议 | 自发货之日起，-20°C可稳定保存1年。为最大限度的避免损失，请在打开管盖之前融化抗体并离心。我们建议使用前分装以避免反复冻融。 |
| 运输条件 | 蓝冰运输 |
| 警告 | 本文列出的产品仅供研究使用，不适用于人类或临床诊断。我们产品所推荐应用，不是建议使用我们的产品去违反任何专利或许可证。对于使用本产品可能发生的专利侵权或其他违规行为，我们不承担任何责任。 |
| 其他 | 该抗体可检测内源蛋白 |
| 背景 | CASP3 encodes caspase 3 which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. |
Fig.1. Immunofluorescence analysis of human lung tissue. 1, Caspase-3 多克隆 Antibody (red) was diluted at 1:200 (4°C, overnight). 2, Cy3 Labeled secondary antibody was diluted at 1:300 (room temperature, 50min). 3, Picture B: DAPI (blue) 10min. Picture A: Target. Picture B: DAPI. Picture C: merge of A+B.|||ABP0135-2.jpg
作者：H Luo, Q Huang, D Huang, C Liu 杂志名称：ACS Chem. Neurosci IF：6
作者：H Luo, Q Huang, D Huang, C Liu 杂志名称：ACS Chem. Neurosci IF：6
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