产品英文名称 | Catenin-β Polyclonal Antibody |
产品中文名称 | 连环蛋白β多克隆抗体 |
别名 | CTNNB1; CTNNB; OK/SW-cl.35; Catenin beta-1; Beta-catenin |
克隆类型 | 多克隆 |
检测类型 | WB |
反应性 | 大鼠,小鼠,人 |
宿主 | 兔 |
浓度 | 1 mg/ml |
免疫原 | 合成多肽:人源蛋白Catenin-β,非磷酸化多肽,中心氨基酸为S33. |
样本类型 | WB# IHC-P# IF# ELISA |
产品形式 | 液体形式 |
基因ID | 1499 |
目标条带分子量 | 85 |
蛋白序列链接 | http://www.uniprot.org/uniprot/P35222 |
存储缓冲液 | 含有50%甘油,0.5%BSA和0.02%叠氮化钠的PBS缓冲液。 |
保存建议 | 自发货之日起,-20°C可稳定保存1年。为最大限度的避免损失,请在打开管盖之前融化抗体并离心。我们建议使用前分装以避免反复冻融。 |
运输条件 | 蓝冰运输 |
警告 | 本文列出的产品仅供研究使用,不适用于人类或临床诊断。我们产品所推荐应用,不是建议使用我们的产品去违反任何专利或许可证。对于使用本产品可能发生的专利侵权或其他违规行为,我们不承担任何责任。 |
其他 | 该抗体可检测内源蛋白 |
背景 | The protein (catenin beta 1) encoded by CTNNB1 is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in CTNNB1 are a cause of colorectal cancer (CRC, pilomatrixoma (PTR, medulloblastoma (MDB, and ovarian cancer. Three transcript variants encoding the same protein have been found for CTNNB1. |
Fig.1. Western Blot analysis of various cells using Catenin-β Polyclonal Antibody diluted at 1:2000.|||Abp50865-2.jpg