产品英文名称 | Mouse IL-17A Protein |
产品中文名称 | 重组小鼠白介素17A(IL-17A) |
别名 | interleukin 17A, CTLA-8, IL17, IL17A |
序列 | 氨基酸序列来源于:小鼠源IL17A (Thr22-Ala158) (Q62386) 表达的蛋白片段。 |
活性 | Testing in Progress |
蛋白长度 | 重组小鼠IL-17A由137个氨基酸组成,预测分子量为15.4KD |
纯度 | > 98 % ,使用SDS-PAGE检测 |
特点&优势 | 通过LAL法测定,每微克蛋白里内毒素含量<0.1 EU。 |
产品形式 | 冻干粉,冻干缓冲液为无菌的20 mM Tris,50 mM NaCl,pH 8.0。 |
基因ID | 16171 |
蛋白序列链接 | https://www.uniprot.org/uniprotkb/Q62386/entry#sequences |
使用中注意事项 | 开盖使用前,请先离心。本产品为冻干粉,推荐用该产品配套的Reconstitution Buffer进行复溶,且浓度不低于104 µg/mL。客户可根据后续的实验需求,进行进一步的稀释。 |
保存建议 | 本产品为冻干粉形式,建议:将冻干粉产品保存于-20℃以下的干燥环境中。本产品溶解之后,可在4℃保存2-7天,长期使用请置于-20℃以下。为长期保存,推荐添加载体蛋白(0.1% HSA或者BSA),并酌情分装保存,避免反复冻融。 |
运输条件 | 冰袋运输(蓝冰) |
警告 | 本文列出的产品仅供研究使用,不适用于人类或临床诊断。我们产品所推荐应用,不是建议使用我们的产品去违反任何专利或许可证。对于使用本产品可能发生的专利侵权或其他违规行为,我们不承担任何责任。 |
背景 | Interleukin-17 (IL-17) is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. Mature mouse IL-17A shares 61% and 89% amino acid sequence identity with human and rat IL-17A, respectively. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation. |
Fig.Mouse IL17A Protein