| 产品英文名称 | Human RSPO1/R-spondin-1 Protein |
| 产品中文名称 | 重组人RSPO1/R-spondin-1 蛋白（RSPO1/R-spondin-1） |
| 别名 | RSPO1, Roof plate-specific spondin-1 |
| 序列 | 氨基酸序列来源于：人源RSPO1 (Q2MKA7) (Ser21-Ala263) 表达的蛋白片段。 |
| 活性 | Testing in Progress |
| 蛋白长度 | 重组人RSPO1 由243个氨基酸组成，预测分子量为26.7 KD。 |
| 纯度 | > 98 % ，使用SDS-PAGE检测 |
| 特点&优势 | 通过LAL法测定，每微克蛋白里内毒素含量<0.1 EU。 |
| 产品形式 | 冻干粉，冻干缓冲液为无菌的20 mM Tris，50 mM NaCl，pH 8.0。 |
| 基因ID | 284654 |
| 蛋白序列链接 | RSPO1 - R-spondin-1 - Homo sapiens (Human) | UniProtKB | UniProt |
| 使用中注意事项 | 开盖使用前，请先离心。本产品为冻干粉，推荐用该产品配套的Reconstitution Buffer进行复溶，且浓度不低于108 µg/mL。客户可根据后续的实验需求，进行进一步的稀释。 |
| 保存建议 | 本产品为冻干粉形式，建议：将冻干粉产品保存于-20℃以下的干燥环境中。本产品溶解之后，可在4℃保存2-7天，长期使用请置于-20℃以下。为长期保存，推荐添加载体蛋白（0.1% HSA或者BSA），并酌情分装保存，避免反复冻融。 |
| 运输条件 | 冰袋运输（蓝冰） |
| 警告 | 本文列出的产品仅供研究使用，不适用于人类或临床诊断。我们产品所推荐应用，不是建议使用我们的产品去违反任何专利或许可证。对于使用本产品可能发生的专利侵权或其他违规行为，我们不承担任何责任。 |
| 背景 | RSPO1 is a secreted protein,containing 2 FU (furin-like) repeats and 1 TSP type-1 domain and belonging to the R-spondin family. RSPO1 is required for the early development of gonads, regardless of sex. It has been found in mice only eleven days after fertilization. To induce cell proliferation, it acts synergistically with WNT4. They help stabilize β catenin, which activates downstream targets. RSPO1 is necessary in female sex development. It augments the WNT/β catenin pathway to oppose male sex development. In critical gonadal stages, between six and nine weeks after fertilization, the ovaries upregulate it while the testes downregulate it. RSPO1 can potentially aid in the treatment of mucositis, which is characterized by inflammation of the oral cavity. This unfortunate condition often accompanies chemotherapy and radiation in cancer patients with head and neck tumors. |
Fig.Human RSPO1 Protein
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