| 产品英文名称 | Human NRG1 Beta1 Protein |
| 产品中文名称 | 重组人神经调节蛋白1-β1 |
| 别名 | ARIA; NRG1; GGF; HGL; HRG; HRGA; NDF; SMDF; Acetylcholine receptor-inducing activity; Glial growth factor; Heregulin; Neu differentiation factor; Sensory and motor neuron-derived factor |
| 序列 | 氨基酸序列来源于：重组人调蛋白-1 β1 Q02297 (S20-K241) 表达的蛋白片段。 |
| 活性 | Testing in Progress |
| 蛋白长度 | 重组人调蛋白-1 β1由220个氨基酸组成，预测分子量为24.04 KD。 |
| 纯度 | > 99% ，使用SDS-PAGE检测 |
| 特点&优势 | 通过LAL法测定，每微克蛋白里内毒素含量<1.0 EU。 |
| 产品形式 | 冻干粉，冻干缓冲液为无菌的20 mM Tris，150 mM NaCl，pH 7.4。 |
| 基因ID | 142445 |
| 蛋白序列链接 | NRG1 - Pro-neuregulin-1, membrane-bound isoform - Homo sapiens (Human) | UniProtKB | UniProt |
| 使用中注意事项 | 开盖使用前，请先离心。本产品为冻干粉，推荐用该产品配套的Reconstitution Buffer进行复溶，且浓度不低于100 µg/mL。客户可根据后续的实验需求，进行进一步的稀释。 |
| 保存建议 | 本产品为冻干粉形式，建议：将冻干粉产品保存于-20℃以下的干燥环境中。本产品溶解之后，可在4℃保存2-7天，长期使用请置于-20℃以下。为长期保存，推荐添加载体蛋白（0.1% HAS/BSA或10%FBS），并酌情分装保存，避免反复冻融。 |
| 运输条件 | 冰袋运输（蓝冰） |
| 警告 | 本文列出的产品仅供研究使用，不适用于人类或临床诊断。我们产品所推荐应用，不是建议使用我们的产品去违反任何专利或许可证。对于使用本产品可能发生的专利侵权或其他违规行为，我们不承担任何责任。 |
| 背景 | Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44 kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by the usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis. |
Fig.Human NRG1 Beta1 Protein
产品中心
技术中心
