| 产品英文名称 | Mouse GM-CSF protein |
| 产品中文名称 | 重组小鼠粒细胞-巨噬细胞集落刺激因子（GM-CSF） |
| 别名 | CSF; CSF2; CSF-2; GMCSF; GM-CSF;colony stimulating factor 2 (granulocyte-macrophage); granulocyte-macrophage colony-stimulating factor; Colony-stimulating factor; GMCSF, granulocyte-macrophage colony stimulating factor; molgramostin; Sargramostim, MGC131935; MGC138897; Molgramostim; |
| 分子 | GM-CSF |
| 标签 | 无标签 |
| 种属 | 小鼠 |
| 序列 | Amino acid sequence derived from Mouse GM-CSF protein isoform (P01587，Met1-Lys141) was expressed. |
| 活性 | 通过其在FDC-P1细胞中诱导增殖的能力在0.009-2.5 ng/mL的线性范围内测量。 |
| 蛋白长度 | 重组小鼠GM-CSF蛋白由128个氨基酸组成，预测分子量为14.6 kDa。 在还原条件下，SDS-PAGE中小鼠GM-CSF蛋白的表观分子量约为15-25 kDa。 |
| 纯度 | ≥ 90 % ，使用SDS-PAGE检测 |
| 特点&优势 | 采用 LAL 法检测，每 1 μg 蛋白质中的 EU 含量小于 1.0。 |
| 产品形式 | 冻干粉，冻干缓冲液为无菌的 PBS，pH 7.4。 |
| 基因ID | 12981 |
| 蛋白序列链接 | http://www.uniprot.org/uniprot/P01587 |
| 使用中注意事项 | 开盖使用前，请先离心。本产品为冻干粉，推荐用该产品配套的Reconstitution Buffer进行复溶，且浓度不低于100 µg/mL。客户可根据后续的实验需求，进行进一步的稀释。 |
| 保存建议 | 本产品为冻干粉形式，建议：将冻干粉的重组小鼠粒细胞-巨噬细胞集落刺激因子（GM-CSF）产品保存于-20℃以下的干燥环境中。本产品溶解之后，可在4℃保存2-7天，长期使用请置于-20℃以下。为长期保存，推荐添加载体蛋白（0.1% HSA或者BSA），并酌情分装保存，避免反复冻融。 |
| 运输条件 | 常温运输 |
| 警告 | 本文列出的产品仅供研究使用，不适用于人类或临床诊断。我们产品所推荐应用，不是建议使用我们的产品去违反任何专利或许可证。对于使用本产品可能发生的专利侵权或其他违规行为，我们不承担任何责任。 |
| 背景 | The granulocyte-macrophage colony-stimulating factor (GM-CSF) is an important hematopoietic growth factor and immune modulator. GM-CSF also has profound effects on the functional activities of various circulating leukocytes. It is produced by a variety of cell types including T cells, macrophages, endothelial cells and fibroblasts upon receiving immune stimuli. Although GM-CSF is produced locally, it can act in a paracrine fashion to recruit circulating neutrophils, monocytes and lymphocytes to enhance their functions in host defense. GM-CSF was initially classified as a hematopoietic growth factor. However, unlike its close relatives macrophage CSF (M-CSF) and granulocyte CSF (G-CSF), the majority of myeloid cells do not require GM-CSF for steady-state myelopoiesis. Instead, in inflammation, GM-CSF serves as a communication conduit between tissue-invading lymphocytes and myeloid cells. Even though lymphocytes are in all likelihood the instigators of chronic inflammatory disease, GM-CSF-activated phagocytes are well equipped to cause tissue damage. |
Fig.SDS-PAGE analysis of Mouse GM-CSF protei.
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