产品英文名称 | Active Caspase-3 Monoclonal Antibody |
产品中文名称 | Active Caspase-3 单克隆抗体 |
克隆类型 | 单克隆 |
检测类型 | WB,IF,IHC-P |
反应性 | 小鼠,人,鸡,大鼠 |
宿主 | 小鼠 |
浓度 | 1 mg/ml |
免疫原 | 重组蛋白 |
样本类型 | WB#IF#IHC-P |
产品形式 | 液体形式 |
基因ID | 836 |
蛋白序列链接 | http://www.uniprot.org/uniprot/P42574 |
存储缓冲液 | PBS缓冲液(pH 7.4),含有0.02%叠氮化钠(防腐剂)和50%甘油。 |
保存建议 | 自发货之日起,-20°C可稳定保存1年。为最大限度的避免损失,请在打开管盖之前融化抗体并离心。我们建议使用前分装以避免反复冻融。 |
运输条件 | 蓝冰运输 |
警告 | 本文列出的产品仅供研究使用,不适用于人类或临床诊断。我们产品所推荐应用,不是建议使用我们的产品去违反任何专利或许可证。对于使用本产品可能发生的专利侵权或其他违规行为,我们不承担任何责任。 |
其他 | 该抗体可检测内源蛋白 |
背景 | CASP3 (caspase 3) encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of CASP3 results in two transcript variants that encode the same protein. |
Fig.1. Western blot analysis of 1) Hela, 2) 3T3, 3) rat brain tissue using Active Caspase-3 Monoclonal Antibody.|||ABM0062-2.jpg
作者:Jin H, Hou J, Meng X, Ma T, Wang B, Liu Z, Sha X, Ding J, Han X 杂志名称:Ecotoxicol Environ Saf IF:5
作者:H Jin, J Hou, X Meng 杂志名称:Ecotoxicology and Environmental Safety IF:6