| 产品英文名称 | Phospho-Akt (S473) Mouse Monoclonal Antibody (6F8) |
| 产品中文名称 | 磷酸化丝氨酸/苏氨酸激酶AKT (S473) 小鼠单克隆抗体 (6F8) |
| 别名 | AKT1 |
| 克隆类型 | 单克隆 |
| 检测类型 | WB |
| 反应性 | 人 |
| 宿主 | 小鼠 |
| 浓度 | 1 mg/ml |
| 免疫原 | 合成多肽： Phospho-Akt (S473)多肽，410-490位氨基酸 |
| 样本类型 | WB# IHC-P |
| 产品形式 | 液体形式 |
| 基因ID | 207 |
| 目标条带分子量 | 60 |
| 蛋白序列链接 | http://www.uniprot.org/uniprot/P31749 |
| 存储缓冲液 | 含有50％甘油，0.5％BSA和0.02％叠氮化钠的PBS缓冲液。 |
| 保存建议 | 自发货之日起，-20°C可稳定保存1年。为最大限度的避免损失，请在打开管盖之前融化抗体并离心。我们建议使用前分装以避免反复冻融。 |
| 运输条件 | 蓝冰运输 |
| 警告 | 本文列出的产品仅供研究使用，不适用于人类或临床诊断。我们产品所推荐应用，不是建议使用我们的产品去违反任何专利或许可证。对于使用本产品可能发生的专利侵权或其他违规行为，我们不承担任何责任。 |
| 其他 | 该抗体可检测内源蛋白 |
| 背景 | The serine-threonine protein kinase encoded by the AKT1 (AKT serine/threonine kinase 1) gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in AKT1 have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for AKT1. |
Fig.1. Immunohistochemical analysis of paraffin-embedded Human Lung Carcinoma Tissue using Phospho-Akt Ser473 Mouse mAb diluted at 1:200.|||Abm40274-2.jpg
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