| 产品英文名称 | JNK1/2/3 (phospho Thr183/Y185) Polyclonal Antibody |
| 产品中文名称 | c-Jun氨基末端激酶1/2/3 (phospho Thr183/Y185)多克隆抗体 |
| 别名 | MAPK8; JNK1; PRKM8; SAPK1; SAPK1C; Mitogen-activated protein kinase 8; MAP kinase 8; MAPK 8; JNK-46; Stress-activated protein kinase 1c; SAPK1c; Stress-activated protein kinase JNK1; c-Jun N-terminal kinase 1; MAPK9; JNK2; PRKM9; SAPK1A; Mi |
| 克隆类型 | 多克隆 |
| 检测类型 | IF |
| 反应性 | 小鼠,人,鸡,大鼠 |
| 宿主 | 兔 |
| 浓度 | 1 mg/ml |
| 免疫原 | 合成多肽：人源蛋白JNK1/2/3，磷酸化多肽，中心氨基酸为T183/Y185. |
| 样本类型 | IF# WB# IHC-p# ELISA |
| 产品形式 | 液体形式 |
| 基因ID | 5599/5601/5602 |
| 蛋白序列链接 | http://www.uniprot.org/uniprot/P45983 |
| 存储缓冲液 | 含有50％甘油，0.5％BSA和0.02％叠氮化钠的PBS缓冲液。 |
| 保存建议 | 自发货之日起，-20°C可稳定保存1年。为最大限度的避免损失，请在打开管盖之前融化抗体并离心。我们建议使用前分装以避免反复冻融。 |
| 运输条件 | 蓝冰运输 |
| 警告 | 本文列出的产品仅供研究使用，不适用于人类或临床诊断。我们产品所推荐应用，不是建议使用我们的产品去违反任何专利或许可证。对于使用本产品可能发生的专利侵权或其他违规行为，我们不承担任何责任。 |
| 其他 | 该抗体可检测内源蛋白 |
| 背景 | Mitogen-activated protein kinase 8 encoded by MAPK8 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. Mitogen-activated protein kinase 8 is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. Mitogen-activated protein kinase 8 is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of MAPK8 suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. |
Fig.1. Western Blot analysis of KB (1， MCF-7 (2， diluted at 1:2000.|||ABP50351-2.jpg
这两种抗体识别蛋白的磷酸化位点是不一样的，所以功能是不同的，因此不能替代。
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