| 产品英文名称 | Collagen I Mouse Monoclonal Antibody (4H10) |
| 产品中文名称 | 胶原蛋白I小鼠单克隆抗体 (4H10) |
| 别名 | Collagen alpha-1(I) chain; Alpha-1 type I collagen |
| 克隆类型 | 单克隆 |
| 检测类型 | IHC-P |
| 反应性 | 小鼠,人,大鼠 |
| 宿主 | 小鼠 |
| 浓度 | 1 mg/ml |
| 免疫原 | 合成多肽： Collagen I |
| 样本类型 | IHC-P# IF |
| 产品形式 | 液体形式 |
| 基因ID | 1277/1278 |
| 目标条带分子量 | 139 |
| 蛋白序列链接 | http://www.uniprot.org/uniprot/P02452 |
| 存储缓冲液 | PBS缓冲液（pH 7.4），含有0.02％叠氮化钠（防腐剂）和50％甘油。 |
| 保存建议 | 自发货之日起，-20°C可稳定保存1年。为最大限度的避免损失，请在打开管盖之前融化抗体并离心。我们建议使用前分装以避免反复冻融。 |
| 运输条件 | 蓝冰运输 |
| 警告 | 本文列出的产品仅供研究使用，不适用于人类或临床诊断。我们产品所推荐应用，不是建议使用我们的产品去违反任何专利或许可证。对于使用本产品可能发生的专利侵权或其他违规行为，我们不承担任何责任。 |
| 其他 | 该抗体可检测内源蛋白 |
| 背景 | COL1A1 (collagen type I alpha 1 chain) encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in COL1A1 are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for COL1A1. |
Fig.1. Immunohistochemical analysis of paraffin-embedded human lung cancer tissue. 1, Collagen I Mouse Monoclonal Antibody (4H10) was diluted at 1:200 (4°C, overnight). 2, Sodium citrate pH 6.0 was used for antibody retrieval (>98°C, 20min). 3, secondary antibody was diluted at 1:200 (room temperature, 30min). Negative control was used by secondary antibody only.|||ABM40379-2.jpg
作者：M Lecomte, D Tomassi, R Rizzoli, M Tenon, T Berton 杂志名称：Nutrient IF：6
作者：Zhang Y, Li T 杂志名称：J Transl Med IF：4
作者：M Lecomte, D Tomassi, R Rizzoli, M Tenon, T Berton 杂志名称：Nutrient IF：6
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