| 产品英文名称 | Stat3 (phospho Tyr705) Polyclonal Antibody |
| 产品中文名称 | 信号转导因子和转录激活因子3 (phospho Tyr705)多克隆抗体 |
| 别名 | STAT3; APRF; Signal transducer and activator of transcription 3; Acute-phase response factor |
| 克隆类型 | 多克隆 |
| 检测类型 | IF |
| 反应性 | 小鼠,人,大鼠 |
| 宿主 | 兔 |
| 浓度 | 1 mg/ml |
| 免疫原 | 合成多肽：人源蛋白Stat3，磷酸化多肽，中心氨基酸为Y705. |
| 样本类型 | IF# WB# IHC-p# IP# ELISA |
| 产品形式 | 液体形式 |
| 基因ID | 6774 |
| 目标条带分子量 | 88 |
| 蛋白序列链接 | http://www.uniprot.org/uniprot/P40763 |
| 存储缓冲液 | 含有50％甘油，0.5％BSA和0.02％叠氮化钠的PBS缓冲液。 |
| 保存建议 | 自发货之日起，-20°C可稳定保存1年。为最大限度的避免损失，请在打开管盖之前融化抗体并离心。我们建议使用前分装以避免反复冻融。 |
| 运输条件 | 蓝冰运输 |
| 警告 | 本文列出的产品仅供研究使用，不适用于人类或临床诊断。我们产品所推荐应用，不是建议使用我们的产品去违反任何专利或许可证。对于使用本产品可能发生的专利侵权或其他违规行为，我们不承担任何责任。 |
| 其他 | 该抗体可检测内源蛋白 |
| 背景 | Signal transducer and activator of transcription 3 encoded by STAT3 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. Signal transducer and activator of transcription 3 is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. Signal transducer and activator of transcription 3 mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in STAT3 are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
Fig.1. Immunohistochemical analysis of paraffin-embedded human lung cancer tissue. 1, Stat3 (phospho Tyr705) Polyclonal Antibody was diluted at 1:200 (4°C, overnight). 2, Sodium citrate pH 6.0 was used for antibody retrieval (>98°C, 20min). 3, secondary antibody was diluted at 1:200 (room temperature, 30min). Negative control was used by secondary antibody only.|||ABP50407-2.jpg
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