| 产品英文名称 | Caspase-1 Polyclonal Antibody |
| 产品中文名称 | Caspase-1多克隆抗体 |
| 别名 | CASP1; IL1BC; IL1BCE; Caspase-1; CASP-1; Interleukin-1 beta convertase; IL-1BC; Interleukin-1 beta-converting enzyme; ICE; IL-1 beta-converting enzyme; p45 |
| 克隆类型 | 多克隆 |
| 检测类型 | WB |
| 反应性 | 人,大鼠,小鼠 |
| 宿主 | 兔 |
| 浓度 | 1 mg/ml |
| 免疫原 | 合成多肽：人源蛋白Caspase-1，非磷酸化多肽，中心氨基酸为S376. |
| 样本类型 | WB# IHC-P# ELISA |
| 产品形式 | 液体形式 |
| 基因ID | 834 |
| 目标条带分子量 | 29 |
| 蛋白序列链接 | http://www.uniprot.org/uniprot/P29466 |
| 存储缓冲液 | 含有50％甘油，0.5％BSA和0.02％叠氮化钠的PBS缓冲液。 |
| 保存建议 | 自发货之日起，-20°C可稳定保存1年。为最大限度的避免损失，请在打开管盖之前融化抗体并离心。我们建议使用前分装以避免反复冻融。 |
| 运输条件 | 蓝冰运输 |
| 警告 | 本文列出的产品仅供研究使用，不适用于人类或临床诊断。我们产品所推荐应用，不是建议使用我们的产品去违反任何专利或许可证。对于使用本产品可能发生的专利侵权或其他违规行为，我们不承担任何责任。 |
| 其他 | 该抗体可检测内源蛋白 |
| 背景 | CASP1 encodes a protein (caspase 1) which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. |
Fig. Western Blot analysis of various cells using Caspase-1 Polyclonal Antibody diluted at 1:500.
作者：Zeng, Bin, et al. 杂志名称：Pharmacological Research IF：9
作者：Zeng, Bin, et al. 杂志名称：Pharmacological Research IF：9
产品中心
技术中心
