产品英文名称 | Human FGF-19 Protein, His tag |
产品中文名称 | 重组人成纤维生长因子19,His-标签(FGF19) |
别名 | fibroblast growth factor 19, FGFJ, FGF19 |
序列 | 氨基酸序列来源于:人源 FGF19 (Arg22-Lys216) (O95750) 表达的蛋白片段。 |
活性 | Testing in Progress |
蛋白长度 | 重组人FGF19 由195个氨基酸组成,预测分子量为21.8 KD。 |
纯度 | > 98 % ,使用SDS-PAGE检测 |
特点&优势 | 通过LAL法测定,每微克蛋白里内毒素含量<0.1 EU。 |
产品形式 | 冻干粉,冻干缓冲液为无菌的20 mM Tris, 50 mM NaCl, pH8.0. |
基因ID | 9965 |
蛋白序列链接 | FGF19 - Fibroblast growth factor 19 - Homo sapiens (Human) | UniProtKB | UniProt |
使用中注意事项 | 开盖使用前,请先离心。本产品为冻干粉,推荐用该产品配套的Reconstitution Buffer进行复溶,且浓度不低于100 µg/mL。客户可根据后续的实验需求,进行进一步的稀释。 |
保存建议 | 本产品为冻干粉形式,建议:将冻干粉产品保存于-20℃以下的干燥环境中。本产品溶解之后,可在4℃保存2-7天,长期使用请置于-20℃以下。为长期保存,推荐添加载体蛋白(0.1% HSA或者BSA),并酌情分装保存,避免反复冻融。 |
运输条件 | 冰袋运输(蓝冰) |
警告 | 本文列出的产品仅供研究使用,不适用于人类或临床诊断。我们产品所推荐应用,不是建议使用我们的产品去违反任何专利或许可证。对于使用本产品可能发生的专利侵权或其他违规行为,我们不承担任何责任。 |
背景 | Fibroblast growth factor 19 (FGF-19) is a secreted protein which belongs to the FGFs family. FGF-19 is expressed in fetal brain, cartilage, retina, and adult gall bladder. FGFs modulate cellular activity via at least 5 distinct subfamilies of high-affinity FGF receptors (FGFRs): FGFR-1, -2, -3, and -4, all with intrinsic tyrosine kinase activity. FGFRs can be important for regulation of glucose and lipid homeostasis. FGF19 has important roles as a hormone produced in the ileum in response to bile acid absorption. It has been shown to cause resistance to diet-induced obesity and insulin desensitization and to improve insulin, glucose, and lipid profiles in diabetic rodents. FGF-19 can be considered as a regulator of energy expenditure. |
Fig.Human FGF-19 Protein, His tag